Balldin J, Blennow K, Bråne G, Gottfries C G, Karlsson I, Regland B, Wallin A
University of Göteborg, Department of Clinical Neuroscience, Mölndal Hospital, Sweden.
Dementia. 1994 Sep-Oct;5(5):252-6. doi: 10.1159/000106733.
In 40 patients with Alzheimer's disease (AD, < 65 years), 56 patients with senile dementia of the Alzheimer type (SDAT, > or = 65 years) and 45 patients with vascular dementia (VAD), basal cortisol levels were estimated and the dexamethasone test (DST) was performed. The degree of dementia was assessed according to DSM-III-R and the GBS scale was used for quantitative measures of functional impairment. There were no significant differences in basal cortisol levels. Especially in the VAD group, scores on functional impairment correlated significantly with post-DST cortisol levels. The results indicate hypothalamic overactivity in demented patients which can be correlated to the degree of dementia. In VAD, and to a certain extent also in SDAT, there appears to be a disconnection between cortical areas, including the hippocampus and the hypothalamus.
对40例阿尔茨海默病（AD，年龄＜65岁）患者、56例阿尔茨海默型老年痴呆症（SDAT，年龄≥65岁）患者和45例血管性痴呆（VAD）患者，测定其基础皮质醇水平并进行地塞米松试验（DST）。根据《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）评估痴呆程度，并使用总体行为量表（GBS）对功能损害进行定量测量。基础皮质醇水平无显著差异。特别是在VAD组，功能损害评分与DST后皮质醇水平显著相关。结果表明痴呆患者存在下丘脑功能亢进，这与痴呆程度相关。在VAD中，在一定程度上也在SDAT中，包括海马体和下丘脑在内的皮质区域之间似乎存在脱节。
