Gaspary João Francisco Pollo, Lopes Luis Felipe Dias, Camara Antonio Geraldo
Instituto AuBento - Center for Teaching, Clinical Practice and Research in Orthomolecular and Translational Health Innovation, Santa Maria, Brazil.
Federal University of Santa Maria, Santa Maria, Brazil.
Front Psychiatry. 2025 Apr 29;16:1537442. doi: 10.3389/fpsyt.2025.1537442. eCollection 2025.
It is increasingly recognized that the brain continuously interacts with other body systems such as the immune system, the gut-brain axis, and the endocrine system. Dysfunctions in these systems can impact mental health by altering neurotransmitter levels and the neurochemical environment. This shift in understanding underscores the need for therapeutic strategies that address systemic health and mitochondrial function, alongside psychosocial aspects of the disease, offering a more personalized and adaptive approach to treatment.
This study utilizes a translational research approach structured through the Work Breakdown Structure methodology, dividing the process into six interconnected Work Packages (WPs). These include systematic literature reviews on endocrine dysfunctions and hormonal therapies in mental disorders, application of Design Thinking for neuroendocrine innovation, and hypothesis exploration of hCG as a systemic adjunctive treatment for psychiatric disorders, culminating in result dissemination and evaluation.
Work The study identified multiple mechanistic impacts of human chorionic gonadotropin (hCG) relevant to psychiatric treatment. Key findings from hCG Hormetic Therapy (HHT) include stimulation of sex hormone production, reduction of insulin resistance and systemic inflammation, enhancement of hypothalamic activity to regulate appetite, sleep, and emotions, and LH-like effects on cognition. HHT also increases IGF-1 availability, promoting neuroprotection, cognitive improvements, and reduced mitochondrial dysfunction, restoring cellular function critical for brain health.
The findings underscore the significance of enhancing endocrine and metabolic functions as a viable strategy for improving psychiatric care, aligning with trends that advocate holistic treatment strategies. The suggested dose for future research protocols is 500 IU IM per week for at least 10 weeks.
Supporting diverse and varied research is crucial for advancing medical knowledge. Continuous exploration of neuroendocrine dysfunctions in mental disorders using advanced tools from neuroscience, endocrinology, and psychiatry can provide new pathways for more effective and personalized treatments. The study of HHT effects offers insights into complex neuroendocrine interactions, underscoring the potential for innovative therapeutic strategies in psychiatry.
人们越来越认识到，大脑不断与其他身体系统相互作用，如免疫系统、肠脑轴和内分泌系统。这些系统的功能障碍会通过改变神经递质水平和神经化学环境来影响心理健康。这种认识上的转变凸显了治疗策略的必要性，这些策略不仅要解决疾病的社会心理方面，还要关注全身健康和线粒体功能，从而提供更个性化和适应性更强的治疗方法。
本研究采用通过工作分解结构方法构建的转化研究方法，将过程分为六个相互关联的工作包（WP）。这些工作包包括对精神障碍中内分泌功能障碍和激素疗法的系统文献综述、将设计思维应用于神经内分泌创新、探索人绒毛膜促性腺激素（hCG）作为精神障碍全身辅助治疗的假设，最终进行结果传播和评估。
该研究确定了人绒毛膜促性腺激素（hCG）与精神科治疗相关的多种机制性影响。hCG 应激激素疗法（HHT）的主要发现包括刺激性激素产生、降低胰岛素抵抗和全身炎症、增强下丘脑活动以调节食欲、睡眠和情绪，以及对认知的促黄体生成素样作用。HHT 还增加胰岛素样生长因子-1（IGF-1）的可用性，促进神经保护、认知改善并减少线粒体功能障碍，恢复对大脑健康至关重要的细胞功能。
研究结果强调了增强内分泌和代谢功能作为改善精神科护理的可行策略的重要性，这与倡导整体治疗策略的趋势一致。未来研究方案建议的剂量是每周 500 国际单位肌肉注射，至少持续 10 周。
支持多样化的研究对于推进医学知识至关重要。利用神经科学、内分泌学和精神病学的先进工具持续探索精神障碍中的神经内分泌功能障碍，可以为更有效和个性化的治疗提供新途径。对 HHT 效应的研究为复杂的神经内分泌相互作用提供了见解，凸显了精神病学创新治疗策略的潜力。
