Emile J F, Tartour E, Brugières L, Donadieu J, Le Deist F, Charnoz I, Fischer A, Fridman W H, Brousse N
Service d'Anatomie et de Cytologie Pathologiques, Hôpital Necker-Enfants Malades, Villejuif, France.
Pediatr Allergy Immunol. 1994 Aug;5(3):162-3. doi: 10.1111/j.1399-3038.1994.tb00232.x.
GM-CSF induces proliferation and activation of Langerhans' cells in vitro. The density of Langerhans' cells in human tumours is correlated to the in situ density of GM-CSF, and intradermal injection of GM-CSF induces local accumulation of Langerhans' cells. Therefore, we investigated the presence of GM-CSF in the sera of children with Langerhans' cell histiocytosis (LCH). We detected GM-CSF in the sera of all children with disseminated and active LCH, but not in the sera of patients with localized (i.e. bone) LCH. These results suggest that GM-CSF level is related to extent and the activity of LCH.
粒细胞-巨噬细胞集落刺激因子（GM-CSF）在体外可诱导朗格汉斯细胞增殖和活化。人类肿瘤中朗格汉斯细胞的密度与GM-CSF的原位密度相关，皮内注射GM-CSF可诱导朗格汉斯细胞局部聚集。因此，我们研究了朗格汉斯细胞组织细胞增生症（LCH）患儿血清中GM-CSF的存在情况。我们在所有播散性活动性LCH患儿的血清中检测到了GM-CSF，但在局限性（即骨）LCH患者的血清中未检测到。这些结果表明，GM-CSF水平与LCH的范围和活动度相关。
