对南非金矿工人吸烟和接触矿物粉尘对循环吞噬细胞激活、血浆中维生素C、维生素E和β-胡萝卜素浓度变化以及肺功能障碍的相对贡献的调查。
Investigation of the relative contributions of cigarette smoking and mineral dust exposure to activation of circulating phagocytes, alterations in plasma concentrations of vitamin C, vitamin E, and beta carotene, and pulmonary dysfunction in South African gold miners.
作者信息
Theron A J, Richards G A, Myer M S, van Antwerpen V L, Sluis-Cremer G K, Wolmarans L, van der Merwe C A, Anderson R
机构信息
Department of Immunology, University of Pretoria, South Africa.
出版信息
Occup Environ Med. 1994 Aug;51(8):564-7. doi: 10.1136/oem.51.8.564.
OBJECTIVES
To determine the relative effects of cigarette smoking and mineral dust exposure on numbers and activity of circulating phagocytes, plasma nutritional antioxidant state, and pulmonary function in South African gold miners.
METHODS
Pulmonary function was assessed spirometrically, whereas reactive oxidant generation by circulating phagocytes, and plasma concentrations of the nutritional antioxidative nutrients vitamin C and vitamin E and beta carotene were measured with chemiluminescence, spectrophotometry, or high performance liquid chromatography respectively.
RESULTS
Cigarette smoking, but not mineral dust exposure, was associated with increased numbers and pro-oxidative activity of circulating neutrophils and monocytes, decreased plasma concentrations of vitamin C, and pulmonary dysfunction.
DISCUSSION
In this study group occupational exposure to mineral dust has not been found to promote increases in the numbers or reactivity of circulating phagocytes or to be a significant cause of pulmonary dysfunction, the changes found being due primarily to cigarette smoking.
目的
确定吸烟和接触矿物粉尘对南非金矿工人循环吞噬细胞数量和活性、血浆营养抗氧化状态及肺功能的相对影响。
方法
采用肺量计评估肺功能，分别通过化学发光法、分光光度法或高效液相色谱法测定循环吞噬细胞产生的活性氧化剂以及营养抗氧化营养素维生素C、维生素E和β-胡萝卜素的血浆浓度。
结果
吸烟而非接触矿物粉尘与循环中性粒细胞和单核细胞数量增加及促氧化活性增强、血浆维生素C浓度降低和肺功能障碍有关。
讨论
在该研究组中，未发现职业性接触矿物粉尘会促使循环吞噬细胞数量或反应性增加，也不是肺功能障碍的重要原因，所发现的变化主要归因于吸烟。
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