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[慢性辐射对大鼠骨髓有核细胞细胞周期的影响]

[Effect of chronic irradiation on the cell cycle of rat myelokaryocytes].

作者信息

Iagunov A S, Tokalov S V

出版信息

Radiats Biol Radioecol. 1994 Jul-Oct;34(4-5):556-60.

PMID:7951883
Abstract

Rats were exposed to gamma-radiation within dose range from 0.12 to 4.0 Gy at dose rates from 0.625 microGy/s to 1.1 mGy/s. The changes in myelokaryocyte distribution within the cell cycle phases during the period of 1 to 18 months after irradiation were studied by the method of flow cytometry. A dose-dependent increase of cell percentage in S-phase after irradiation at low dose rates (from 0.625 to 10.0 microGy/s) was found. The effect was kept till the end of irradiated rats life.

摘要

将大鼠暴露于剂量范围为0.12至4.0 Gy、剂量率为0.625微Gy/秒至1.1 mGy/秒的γ辐射中。采用流式细胞术研究了辐照后1至18个月期间细胞周期各阶段骨髓有核细胞分布的变化。发现在低剂量率(0.625至10.0微Gy/秒)辐照后,S期细胞百分比呈剂量依赖性增加。这种效应一直持续到受辐照大鼠生命结束。

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