Wolfe G I, Galetta S L, Mollman J E
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104.
J Neuroophthalmol. 1994 Jun;14(2):91-4. doi: 10.3109/01658109409024031.
Spontaneous regression of hematologic malignancies is not uncommon and occurs in a wide variety of lymphomas and leukemias. In contrast, spontaneous remission of neurologic symptoms produced by these tumors is exceedingly rare. We report a patient with central nervous system acute lymphoblastic leukemia who experienced at least one spontaneous remission of papilledema and sixth nerve palsy. This represents, to our knowledge, the first case of spontaneous remission of neuro-ophthalmologic signs in a patient with acute leukemia. We conclude that meningeal leukemia may have a protracted course, and that spontaneous remission of neuro-ophthalmologic findings should not be so readily ascribed to a benign process in a patient with preexisting leukemia.
血液系统恶性肿瘤的自发消退并不罕见，见于多种淋巴瘤和白血病。相比之下，这些肿瘤所致神经症状的自发缓解极为罕见。我们报告1例中枢神经系统急性淋巴细胞白血病患者，其视乳头水肿和展神经麻痹至少有1次自发缓解。据我们所知，这是急性白血病患者神经眼科体征自发缓解的首例。我们得出结论，脑膜白血病可能病程迁延，而且对于已有白血病的患者，神经眼科表现的自发缓解不应轻易归因于良性过程。
