Díaz E, Pinto-Hamuy T, Fernández V
Department of Physiology & Biophysics, School of Medicine, University of Chile, Santiago.
Eur J Neurosci. 1994 Jul 1;6(7):1235-8. doi: 10.1111/j.1460-9568.1994.tb00622.x.
The effects of a lateralized reaching task on the morphological structure of the rat motor cortex were studied during the early postweaning period. Our results show that the consistent use of one forelimb accounts for a significant decrease in the numerical density of cells and an increase in cortical thickness of the contralateral 'forelimb' motor cortex. As a consequence of the early motor training the cell distribution, which is lower rostrally than caudally in nontrained hemispheres, is reversed in the trained hemispheres. This may be interpreted as the specific motor training triggering a higher neuronal branching in the corresponding cortical region. The present findings may further the understanding of the mechanisms involved in the generation of morphological brain asymmetries.
在断奶后早期，研究了侧向伸展任务对大鼠运动皮层形态结构的影响。我们的结果表明，持续使用一侧前肢会导致对侧“前肢”运动皮层的细胞数量密度显著降低，皮层厚度增加。早期运动训练的结果是，在未训练半球中，细胞分布在嘴侧比尾侧低，而在训练半球中则相反。这可以解释为特定的运动训练触发了相应皮层区域更高的神经元分支。目前的研究结果可能会进一步加深对大脑形态不对称产生机制的理解。
