Sacks F M, Walsh B W
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Curr Opin Lipidol. 1994 Jun;5(3):236-40. doi: 10.1097/00041433-199405030-00012.
Previous findings of increased production of large VLDL particles by estrogen have been confirmed in a trial using estrogen-dominant oral contraceptives. Estrogen has been found to have LDL subclass-specific effects and to shift the distribution of apolipoprotein (apo)E from HDL to VLDL. Several recent studies document decreases in lipoprotein (a) [Lp(a)] levels, but the metabolic mechanism is yet unknown. The effects of progestational agents on lipoprotein metabolism remain unclear in view of conflicting reports.
此前关于雌激素会增加大颗粒极低密度脂蛋白（VLDL）生成的研究结果，已在一项使用雌激素占主导的口服避孕药的试验中得到证实。研究发现，雌激素对低密度脂蛋白（LDL）亚类有特异性影响，并会使载脂蛋白（apo）E的分布从高密度脂蛋白（HDL）转移至极低密度脂蛋白（VLDL）。最近的几项研究记录了脂蛋白（a）[Lp（a）]水平的下降，但其代谢机制尚不清楚。鉴于相互矛盾的报道，孕激素对脂蛋白代谢的影响仍不明确。
