在妊娠后期注入怀孕大鼠体内的脂多糖不会诱发胎儿内毒素血症。

LPS injected into the pregnant rat late in gestation does not induce fetal endotoxemia.

作者信息

Goto M, Yoshioka T, Ravindranath T, Battelino T, Young R I, Zeller W P

机构信息

Department of Pediatrics, Loyola University of Chicago, Stritch School of Medicine, Maywood, IL 60153.

出版信息

Res Commun Mol Pathol Pharmacol. 1994 Jul;85(1):109-12.

PMID:7953189

Abstract

Endotoxin is abortifacient. Abortion may be due to maternal, fetal or combined endotoxemia. The present study was performed to evaluate if fetal rat endotoxemia was induced by maternal endotoxemia in late gestation. An intraperitoneal injection of smooth lipopolysaccharide (Escherichia coli LPS and Shigella flexneri LPS) or rough LPS (Rc mutant Escherichia coli LPS) induced Limulus activity in maternal plasma, but not fetal plasma. These results suggest that fetal rat endotoxemia is not induced during maternal endotoxemia. Thus, the abortion may not be due to fetal endotoxemia.

摘要

内毒素具有堕胎作用。流产可能是由于母体、胎儿或混合性内毒素血症所致。本研究旨在评估妊娠晚期母体的内毒素血症是否会诱发胎鼠的内毒素血症。腹腔注射光滑型脂多糖（大肠杆菌脂多糖和弗氏志贺菌脂多糖）或粗糙型脂多糖（Rc突变型大肠杆菌脂多糖）可诱导母体血浆中的鲎试剂活性，但不能诱导胎儿血浆中的鲎试剂活性。这些结果表明，在母体发生内毒素血症期间，不会诱发胎鼠的内毒素血症。因此，流产可能不是由胎儿内毒素血症引起的。