Woźniak A, Kaczmarek E, Salwa-Zurawska W, Bortkiewicz E, Maciejewski J, Krzymański M
Department of Clinical Pathomorphology, University School of Medicine, Poznań.
Pol J Pathol. 1994;45(3):187-93.
Morphometric analysis was used to evaluate mesangial components in MCD (minimal changes disease), GNMes (mesangial glomerulonephritis), FSG (focal segmental glomerulosclerosis). In GNMes the increase of matrix was found to be generally proportional to the amount of mesangial cells. There are clear statistically significant differences in the ratio of matrix volume to cell component volume and of matrix volume to the whole mesangial area in MCD and GNMes as compared with FSG. In the case of GNMes where morphometric results resemble those in FSG cautious prognosis is recommended as there is a possibility of FSG. This has been confirmed both by the course of the disease and the results of repeated biopsy.
采用形态计量分析来评估微小病变肾病（MCD）、系膜增生性肾小球肾炎（GNMes）、局灶节段性肾小球硬化症（FSG）中的系膜成分。在GNMes中，发现基质增加通常与系膜细胞数量成正比。与FSG相比，MCD和GNMes中基质体积与细胞成分体积之比以及基质体积与整个系膜面积之比存在明显的统计学显著差异。在GNMes中，形态计量结果与FSG相似，鉴于存在发展为FSG的可能性，建议谨慎预后。疾病进程和重复活检结果均证实了这一点。
