免疫缺陷病毒。缺乏Nef则不足。
Immunodeficiency viruses. Not enough sans Nef.
作者信息
Littman D R
机构信息
Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco 94143-0414.
出版信息
Curr Biol. 1994 Jul 1;4(7):618-20. doi: 10.1016/s0960-9822(00)00135-4.
PMID:7953537
Abstract
The nef genes of HIV and SIV are dispensable in vitro, but are essential for viral spread and disease progression in vivo. Nef-induced down-regulation of CD4, the viral receptor, may be the key to this requirement.
摘要
HIV和SIV的nef基因在体外并非必需，但对病毒在体内的传播和疾病进展至关重要。Nef诱导的病毒受体CD4下调可能是这一需求的关键所在。
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