Hillhouse E W
Department of Medicine, Bristol Royal Infirmary, UK.
Brain Res. 1994 Jul 11;650(2):323-5. doi: 10.1016/0006-8993(94)91799-x.
Cytokines are involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis, thus providing a means of communication between the immune and neuroendocrine systems. In this study IL-2 caused a dose-dependent stimulation of AVP secretion from both the intact rat hypothalamus in vitro and hypothalamic cell cultures. IL-2 did not increase the secretion of CRH in either preparation, nor did it prime the cells to respond to a subsequent dose of IL-2. Both preparations, however, were able to respond to known CRH secretagogues such as 5-HT and 56 mM K+. This may provide yet another line of communication between the immune and neuroendocrine systems.
细胞因子参与下丘脑 - 垂体 - 肾上腺（HPA）轴的调节，从而提供了免疫系统与神经内分泌系统之间的一种通讯方式。在本研究中，白细胞介素 - 2（IL - 2）在体外对完整大鼠下丘脑以及下丘脑细胞培养物均引起了精氨酸加压素（AVP）分泌的剂量依赖性刺激。在这两种制备物中，IL - 2均未增加促肾上腺皮质激素释放激素（CRH）的分泌，也未使细胞对后续剂量的IL - 2产生反应增强。然而，这两种制备物均能够对已知的CRH促分泌剂如5 - 羟色胺（5 - HT）和56 mM钾离子作出反应。这可能为免疫系统与神经内分泌系统之间提供了另一种通讯途径。
