大鼠背根神经节神经元中河豚毒素敏感和河豚毒素抗性钠通道的单通道分析
Single-channel analysis of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons.
作者信息
Roy M L, Reuveny E, Narahashi T
机构信息
Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611.
出版信息
Brain Res. 1994 Jul 11;650(2):341-6. doi: 10.1016/0006-8993(94)91803-1.
Tetrodotoxin-sensitive and tetrodotoxin-resistant single sodium channel currents were recorded from rat dorsal root ganglion neurons. The two types of sodium channel currents could be distinguished by the effects of predepolarization, 10 nM tetrodotoxin, and the inactivation during depolarization. Single-channel conductances were calculated to be 6.3 and 3.4 pS in the tetrodotoxin-sensitive and tetrodotoxin-resistant channels, respectively.
从大鼠背根神经节神经元记录到了对河豚毒素敏感和对河豚毒素耐受的单钠通道电流。这两种类型的钠通道电流可通过预去极化、10 nM河豚毒素的作用以及去极化期间的失活来区分。计算得出，对河豚毒素敏感的通道和对河豚毒素耐受的通道的单通道电导分别为6.3和3.4 pS。
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