Alam M N, Mallick B N
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Brain Res Bull. 1994;35(2):171-7. doi: 10.1016/0361-9230(94)90099-x.
The preoptic area is anatomically divided into medial and lateral portions and both are involved in the regulation of sleep-wakefulness and body temperature. We have recently reported the specific role of the adrenoceptors, present in the medial preoptic area, in the regulation of those functions. In this study an attempt was made to investigate the specific participation and contribution of the lateral preoptic area alpha-1 and alpha-2 adrenoceptors in the regulation of sleep-wakefulness and body temperature. Sleep-wakefulness and rectal temperature were simultaneously recorded in freely moving rats, both during day and night, under normal condition and after bilateral local microinjection of either agonist or antagonist of alpha-1 and alpha-2 adrenoceptors into the lateral preoptic area. The results suggest that the lateral preoptic area alpha-2 adrenoceptors are predominantly involved in the regulation of sleep-wakefulness whereas alpha-1 adrenoceptors are more effective in thermoregulation.
视前区在解剖学上分为内侧和外侧部分，两者都参与睡眠 - 觉醒和体温的调节。我们最近报道了内侧视前区存在的肾上腺素能受体在这些功能调节中的特定作用。在本研究中，试图探究外侧视前区α-1和α-2肾上腺素能受体在睡眠 - 觉醒和体温调节中的具体参与情况和作用。在正常条件下以及向外侧视前区双侧局部微量注射α-1和α-2肾上腺素能受体激动剂或拮抗剂后，在白天和夜晚对自由活动的大鼠同时记录睡眠 - 觉醒情况和直肠温度。结果表明，外侧视前区α-2肾上腺素能受体主要参与睡眠 - 觉醒的调节，而α-1肾上腺素能受体在体温调节中更有效。
