Shian W J, Chi C S
Department of Pediatrics, Taichung Veterans General Hospital, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1994 Sep;54(3):182-7.
Clinically, some epileptic syndromes have been linked to febrile convulsions (FC), but the exact relationship between FC and later epilepsy remains a mystery.
Detailed histories of 81 Chinese children among 1950 pediatric epileptics with a history of FC were obtained retrospectively. The clinical courses and risk factors were analyzed.
According to their epileptic patterns, the children were divided into a generalized group (Group G, 45/81), a partial group (Group P, 30/81) and those with severe myoclonic epilepsy in infancy (6/81). Patients of Group P had an earlier age of onset of FC with a larger number of risk factors than those of Group G (p < 0.01), and patients of Group G had a shorter interval from the last FC to later epilepsy than those of Group P (p < 0.01). More risk factors of FC were present in children of Group P; these included especially focal seizures, prolonged duration and retarded psychomotor development (p < 0.01).
For group of epileptics in this study, genetic factors might predispose for the expression of FC and later epilepsy, and anticonvulsant prophylaxis for FC seemed to be unnecessary.
临床上，一些癫痫综合征与热性惊厥（FC）有关，但FC与后期癫痫的确切关系仍是个谜。
回顾性获取1950例有FC病史的小儿癫痫患者中81例中国儿童的详细病史。分析其临床病程及危险因素。
根据癫痫发作类型，这些儿童被分为全身性发作组（G组，45/81）、部分性发作组（P组，30/81）和婴儿严重肌阵挛癫痫组（6/81）。P组患者FC起病年龄更早，危险因素数量多于G组（p<0.01），且G组患者从最后一次FC到后期癫痫的间隔时间短于P组（p<0.01）。P组儿童存在更多的FC危险因素；尤其包括局灶性发作、发作持续时间延长和精神运动发育迟缓（p<0.01）。
对于本研究中的癫痫患者群体，遗传因素可能易导致FC及后期癫痫的发生，且似乎无需对FC进行抗惊厥预防。
