托拉塞米的利尿和血管舒张作用。

Diuretic and vasodilating actions of torasemide.

作者信息

Uchida T, Yamanaga K, Kido H, Ohtaki Y, Watanabe M

机构信息

Green Cross Corporation, Central Research Laboratories, Pharmacology, Osaka, Japan.

出版信息

Cardiology. 1994;84 Suppl 2:14-7. doi: 10.1159/000176452.

DOI:10.1159/000176452

PMID:7954537

Abstract

The pharmacological profile of torasemide was examined in experimental animals. In normotensive Wistar rats, torasemide produced less kaliuresis at doses that were equipotent with furosemide in terms of natriuresis. Torasemide but not furosemide exerted a significant diuretic action in rats treated with deoxycorticosterone acetate. Both torasemide and furosemide increased plasma renin activity and aldosterone concentration, but only torasemide significantly inhibited aldosterone-receptor binding in rat kidney. Torasemide also inhibited vasoconstriction induced by thromboxane A2 in isolated canine coronary artery.

摘要

在实验动物中研究了托拉塞米的药理学特性。在血压正常的Wistar大鼠中，托拉塞米在产生与呋塞米等效利钠作用的剂量下，产生的尿钾排泄较少。托拉塞米而非呋塞米在接受醋酸脱氧皮质酮治疗的大鼠中发挥了显著的利尿作用。托拉塞米和呋塞米均增加血浆肾素活性和醛固酮浓度，但只有托拉塞米显著抑制大鼠肾脏中的醛固酮受体结合。托拉塞米还抑制了离体犬冠状动脉中血栓素A2诱导的血管收缩。