Eichelberger M, Doherty P C
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Cell Immunol. 1994 Nov;159(1):94-102. doi: 10.1006/cimm.1994.1298.
Bronchoalveolar lavage (BAL) populations recovered from mice with secondary influenza pneumonia contain gamma delta T cell receptor (TCR)+NK1.1- lymphocytes and gamma delta TCR-NK1.1+ natural killer (NK) cell populations. Stimulating the CD4-8- component of the BAL with a monoclonal antibody to CD3 epsilon and rIL-2 leads to the emergence of substantial numbers of CD4-8- gamma delta TCR+NK1.1+ and CD4-8- alpha beta TCR+NK1.1+ lymphocytes. The NK1.1+ gamma delta T cells are potent cytotoxic effectors, causing much higher lysis of YAC-1 target cells than the gamma delta TCR+NK1.1- lymphocytes that are present concurrently. CD4+ and CD8+ alpha beta T cells cultured in the same way express little (if any) NK1.1. The possible functional role of NK1.1+ gamma delta T cells is discussed.
从患有继发性流感肺炎的小鼠中回收的支气管肺泡灌洗（BAL）细胞群体包含γδT细胞受体（TCR）+NK1.1-淋巴细胞和γδTCR-NK1.1+自然杀伤（NK）细胞群体。用抗CD3ε单克隆抗体和重组白细胞介素-2刺激BAL的CD4-8-组分，会导致大量CD4-8-γδTCR+NK1.1+和CD4-8-αβTCR+NK1.1+淋巴细胞出现。NK1.1+γδT细胞是有效的细胞毒性效应器，与同时存在的γδTCR+NK1.1-淋巴细胞相比，对YAC-1靶细胞的裂解作用要强得多。以同样方式培养的CD4+和CD8+αβT细胞几乎不表达（如果有表达的话）NK1.1。本文讨论了NK1.1+γδT细胞可能的功能作用。
