Studies on agents with vasodilator and beta-blocking activities. I.
作者信息
Seki T, Takezaki T, Ohuchi R, Ohuyabu H, Ishimori T, Yasuda K
机构信息
Research Division, Teikoku Hormone Manufacturing Co., Ltd., Kanagawa, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1994 Aug;42(8):1609-16. doi: 10.1248/cpb.42.1609.
PMID:7954913
Abstract
A series of hydrazinopyridazine derivatives combined with a beta-blocking side chain were synthesized. When they were given intravenously to anesthetized rats, some of them exhibited both hypotensive and beta-blocking activities. Their structure-activity relationships for hypotensive and beta-blocking activities are discussed. Compound 11c had the best profile and was selected for further study.
摘要
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