Ohwada J, Umeda I, Ontsuka H, Aoki Y, Shimma N
Nippon Roche Research Center, Kamakura, Japan.
Chem Pharm Bull (Tokyo). 1994 Aug;42(8):1703-5. doi: 10.1248/cpb.42.1703.
A new antifungal substance, azoxybacilin (an unusual amino acid with an azoxy moiety) and its derivatives have been synthesized from Boc-L-Asp-OtBu utilizing the Moss procedure for the preparation of the azoxy moiety. The ester derivative, Ro 09-1824, showed more potent antifungal activity and a broader antifungal spectrum than azoxybacilin did.
