Synthesis and structure-activity relationships of a novel antifungal agent, azoxybacilin.
作者信息
Ohwada J, Umeda I, Ontsuka H, Aoki Y, Shimma N
机构信息
Nippon Roche Research Center, Kamakura, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1994 Aug;42(8):1703-5. doi: 10.1248/cpb.42.1703.
PMID:7954924
Abstract
A new antifungal substance, azoxybacilin (an unusual amino acid with an azoxy moiety) and its derivatives have been synthesized from Boc-L-Asp-OtBu utilizing the Moss procedure for the preparation of the azoxy moiety. The ester derivative, Ro 09-1824, showed more potent antifungal activity and a broader antifungal spectrum than azoxybacilin did.
摘要
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