[晚期胃癌中DNA含量与生物学特性及预后的关系]
[Relation of DNA content to biological characteristics and prognosis in advanced gastric carcinoma].
作者信息
Li J Y, Lu L R, Zhang S X
机构信息
Department of General Surgery, 304 Hospital of PLA, Beijing.
出版信息
Zhonghua Bing Li Xue Za Zhi. 1994;23(3):135-7.
Cellular DNA ploidy and S-phase fraction from 57 advanced gastric carcinomas were measured by flow cytometry. The relation of DNA ploidy and S-phase fraction to pathological factors and prognosis were also analyzed. The results showed that the incidence of lymph node metastasis in nondiploid carcinoma was substantially higher than that in diploid carcinoma (P < 0.05). Most of the gastric carcinomas with low S-phase fraction were stage II tumors, had no lymph node metastasis, presented expanding growth and had not invaded the serosa (P < 0.05 respectively). The patients with low S-phase fraction carcinoma had remarkably better survival than those with high S-phase fraction (P < 0.01). Multivariate analysis of Cox model demonstrated that S-phase fraction was the best prognostic factor.
采用流式细胞术检测57例进展期胃癌的细胞DNA倍体及S期细胞比例，并分析DNA倍体和S期细胞比例与病理因素及预后的关系。结果显示，非二倍体癌的淋巴结转移发生率显著高于二倍体癌（P<0.05）。大多数S期细胞比例低的胃癌为Ⅱ期肿瘤，无淋巴结转移，呈膨胀性生长，未侵犯浆膜（分别为P<0.05）。S期细胞比例低的患者生存率明显高于S期细胞比例高的患者（P<0.01）。Cox模型多因素分析表明，S期细胞比例是最佳预后因素。
Zotero 插件