Zamboni G, Scarpa A, Capelli P
Istituto di Anatomia Patologica, Università di Verona.
Chir Ital. 1994;46(2):11-25.
Histological, immunohistochemical, and ultrastructural data accumulated in recent years have provided the basis for a more detailed classification of pancreatic cancer. This classification defines new tumour entities with distinct clinicopathologic and prognostic features. Unfortunately, morphologic and phenotypic studies of the more common ductal pancreatic cancer do not provide sufficient information to predict their clinical behaviour. The new field of investigation on genetic abnormalities in pancreatic cancer has not yet provided sufficient data to propose any genetically based classification or prognostic assessment. However, if there is some hope for prevention or cure, this will depend on efforts to clarify the molecular basis of the disease. These features could help in addressing epidemiological studies, in finding markers for diagnosis and prognosis, and might be helpful in devising completely new therapeutic approaches.
近年来积累的组织学、免疫组织化学和超微结构数据为胰腺癌更详细的分类提供了基础。这种分类定义了具有不同临床病理和预后特征的新肿瘤实体。不幸的是，对更常见的导管腺癌的形态学和表型研究未能提供足够信息来预测其临床行为。胰腺癌基因异常这一研究新领域尚未提供足够数据来提出任何基于基因的分类或预后评估。然而，如果在预防或治愈方面有希望的话，这将取决于为阐明该疾病分子基础所做的努力。这些特征有助于开展流行病学研究、寻找诊断和预后标志物，并且可能有助于设计全新的治疗方法。
