Velísková J, Garant D S, Xu S G, Moshé S L
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461.
Brain Res Dev Brain Res. 1994 Jun 17;79(2):297-300. doi: 10.1016/0165-3806(94)90135-x.
To determine whether the substantia nigra GABAergic anticonvulsant effects depend on GABAB receptor activation, we tested the effects of intranigral CGP 35,348 (a GABAB receptor antagonist) alone or in combination with gamma-vinyl-GABA (GVG; a GABA-transaminase inhibitor) on flurothyl seizures in rat pups and adult rats. In pups, nigral infusions of CGP 35,348 decreased the thresholds for clonic and tonic seizures and attenuated the anticonvulsant effects of GVG. In adults, nigral infusions of CGP 35,348 did not alter seizure thresholds. The data suggest that, in rat pups, nigral GABAB receptors regulate, in part, flurothyl-induced seizures.
为了确定黑质GABA能抗惊厥作用是否依赖于GABAB受体激活，我们测试了脑内注射CGP 35,348（一种GABAB受体拮抗剂）单独或与γ-乙烯基-GABA（GVG；一种GABA转氨酶抑制剂）联合使用对幼鼠和成年大鼠氟烷惊厥的影响。在幼鼠中，脑内注射CGP 35,348降低了阵挛性和强直性惊厥的阈值，并减弱了GVG的抗惊厥作用。在成年大鼠中，脑内注射CGP 35,348未改变惊厥阈值。数据表明，在幼鼠中，黑质GABAB受体部分调节氟烷诱导的惊厥。
