Michelsson J E, Juntunen S, Valtakari T, Mikkola J
Division of Orthopaedic Surgery and Traumatology, Surgical Hospital, Helsinki University Central Hospital, Finland.
Clin Exp Rheumatol. 1994 Jul-Aug;12(4):409-13.
The effect of methylprednisolone administered following manipulation of the immobilized knee of 35 adult rabbits was investigated. In the legs of 15 control rabbits which received no methylprednisolone, heterotopic cartilage and bone in the periarticular tissues and in the vastus intermedius muscle, and extensive knee stiffening and thickening regularly developed. In the other rabbits, methylprednisolone showed a marked preventive effect on the development of all these pathological signs.
研究了对35只成年兔固定膝关节进行手法操作后给予甲泼尼龙的效果。在15只未接受甲泼尼龙的对照兔的腿部，关节周围组织和股中间肌中出现了异位软骨和骨，并且经常出现广泛的膝关节僵硬和增厚。在其他兔子中，甲泼尼龙对所有这些病理体征的发展显示出显著的预防作用。
