Hokezu Y, Higuchi I, Yanai S, Nagai M, Nagamatsu K
Department of Neurology, Oita Prefectural Hospital.
Rinsho Shinkeigaku. 1994 Jun;34(6):563-8.
We reported a family case of HAM and HTLV-I carrier including two sisters presenting with myositis. Both the 65-year-old elder sister and her 53-year-old younger sister initially noted lumbago and developed difficulty in walking several years later. Neurologic examination revealed muscle weakness of the proximal parts of the upper and lower limbs (especially the latter). Mild hyperreflexia in all extremities, urinary disturbance and constipation were detected in the elder sister, while only urinary disturbance and constipation were seen in the younger. Anti-HTLV-I antibody in both serum and CSF was positive in both sisters. Muscle biopsy specimens showed features of myositis with perivascular, perimysial and endomysial lymphocyte infiltration. Although an association between HTLV-I and polymyositis had not yet been established, we think that our cases support such an association.
我们报告了一例包括两名患有肌炎的姐妹的HAM和HTLV-I携带者家族病例。65岁的姐姐和53岁的妹妹最初都出现腰痛，几年后出现行走困难。神经系统检查发现上肢和下肢近端肌肉无力（以下肢尤为明显）。姐姐四肢存在轻度反射亢进、排尿障碍和便秘，而妹妹仅出现排尿障碍和便秘。姐妹俩的血清和脑脊液中抗HTLV-I抗体均呈阳性。肌肉活检标本显示为肌炎特征，伴有血管周围、肌束膜和肌内膜淋巴细胞浸润。尽管HTLV-I与多发性肌炎之间的关联尚未确立，但我们认为我们的病例支持这种关联。
