Agostino A, Parenzi A, D'Amore F
Divisione II Medicina Interna, USL RM/3, Ospedale S. Pertini di Roma.
Clin Ter. 1994 Jul;145(7):19-25.
The case is reported of a 70-year-old man with decompensated non-acidotic type-2 diabetes mellitus and with rhinocerebral mucormycosis, manifested by inflammatory infiltration of the left nasal, paranasal, maxillary, and orbital bone structures with left ophthalmoplegia. The patient was cured after amphotericin B treatment (total dose 2.7 g) and 30 sessions of hyperbaric oxygen (2.8 atmospheres). Cure was confirmed by follow-up over more than 2 years. It is concluded that rhinocerebral mucormycosis must be treated, in addition to control of predisposing factors, and especially by restoring endocrine-metabolic balance, by adequate surgical revision, with specific high-dose amphotericin B treatment and adjunctive hyperbaric oxygen. Further studies are desirable in order to define the advantages of these therapeutic measures.
报告了一例70岁男性患者，患有失代偿性非酸中毒型2型糖尿病并伴有鼻脑毛霉菌病，表现为左侧鼻腔、鼻窦、上颌骨和眼眶骨结构的炎症浸润以及左侧眼肌麻痹。患者在接受两性霉素B治疗（总剂量2.7 g）和30次高压氧治疗（2.8个大气压）后治愈。经过2年多的随访证实已治愈。得出的结论是，除了控制诱发因素外，鼻脑毛霉菌病必须通过充分的手术修正、特定的高剂量两性霉素B治疗和辅助高压氧治疗来进行治疗，尤其是通过恢复内分泌代谢平衡。为了确定这些治疗措施的优势，需要进一步的研究。
