Alberti B, Campatelli A, Antonelli A, Di Vito A, Francese C, Saracino A, Agostini S, Baschieri L
Istituto di Clinica Medica II, Università degli Studi di Pisa.
Clin Ter. 1994 Jul;145(7):27-33.
We have reexamined a series of 1119 patients consecutively submitted to fine needle aspiration of nodules of the neck. Among these in 166 cases ultrasonography combined with aspiration suggested the presence of cysts. 60 patients were submitted to cyst aspiration and 34 were aspirated and submitted to cyst injection with tetracycline hydrochloride. The patients were followed up clinically and ultrasonically 3 and 12 months after treatment. Cure was defined as the absence of any residual cystic lesion and an ultrasonic cyst volume less than 50% with respect to basal after 12 months from the start of treatment. 18 of the 60 (30%) patients only aspirated and 24 of the 34 patients (70%) in the tetracycline group were cured (statistically significant; p < 0.005). We conclude that tetracycline seems an effective sclerotherapy in treatment of thyroid cysts.
我们对连续接受颈部结节细针穿刺的1119例患者进行了重新检查。其中，166例经超声检查结合穿刺提示存在囊肿。60例患者接受了囊肿抽吸，34例患者接受了抽吸并注射盐酸四环素。在治疗后3个月和12个月对患者进行临床和超声随访。治愈定义为治疗开始12个月后无任何残留囊性病变，且超声显示囊肿体积较基础值减少50%以下。仅接受抽吸的60例患者中有18例（30%）治愈，四环素组的34例患者中有24例（70%）治愈（具有统计学意义；p<0.005）。我们得出结论，四环素似乎是治疗甲状腺囊肿的一种有效硬化剂。
