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阿奇霉素治疗儿童急性呼吸道感染的临床疗效评估

[Evaluation of the clinical efficacy of azithromycin in acute respiratory infections in children].

作者信息

Bottaro G, Rotolo N, Bonforte S, Bucchieri R, De Luca P, Ficarra G, Gulino A, Melillo P, Nicosia A, Prestifilippo F

机构信息

I Clinica Pediatrica, Università degli Studi di Catania.

出版信息

Clin Ter. 1994 Jul;145(7):35-9.

PMID:7955949
Abstract

Azithromycin activity in vivo has been studied in a group of children with acute respiratory tract infections in order to test the efficacy and tolerability of this antibiotic. The study involved 135 children treated with a single daily 10 mg/kg dose of azithromycin for three consecutive days. Ten days after this treatment 100% of children with otitis media, tracheobronchitis, or rhinosinusitis and 95.9% of children with pharyngo-tonsillitis were cured. Recurrences were never observed. Azithromycin proved remarkably effective for treatment of acute respiratory infections and otitis media in children. Tolerability and therapeutic compliance were excellent.

摘要

为了测试阿奇霉素这种抗生素的疗效和耐受性,对一组患有急性呼吸道感染的儿童进行了阿奇霉素的体内活性研究。该研究涉及135名儿童,他们连续三天每天接受10mg/kg剂量的阿奇霉素治疗。治疗十天后,患有中耳炎、气管支气管炎或鼻窦炎的儿童100%治愈,患有咽扁桃体炎的儿童95.9%治愈。未观察到复发情况。阿奇霉素被证明对治疗儿童急性呼吸道感染和中耳炎非常有效。耐受性和治疗依从性都很好。

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