Kubo S, Matsumoto T, Takahashi K, Haraoka M, Tanaka M, Sakumoto M, Sakamoto Y, Kumazawa J
Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Chemotherapy. 1994 Sep-Oct;40(5):333-6. doi: 10.1159/000239215.
Some of the many antimicrobial agents (beta-lactams, macrolides, aminoglycosides, tetracyclines, new quinolones; NQs) were reported to have a bactericidal or bacteriostatic effect cooperating with host defense mechanisms including polymorphonuclear neutrophils (PMNs). We investigated the effect of new quinolone antimicrobials on chemiluminescence (CL) response of human PMNs. Among many NQs, we chose ofloxacin, lomefloxacin, fleroxacin, sparfloxacin, AM-1155, NM-394, Q-35, Y-26611 and T-3761. Twenty-five or 100 micrograms/ml of fleroxacin and ofloxacin enhanced luminol-dependent CL response of PMNs up to 1.5-2.0 times compared to the drug free condition. Other antimicrobial agents, however, inhibited CL response. This suggested that fleroxacin and ofloxacin were more efficient in the treatment of bacterial infections with respect to the interaction between antimicrobials and PMNs.
据报道，许多抗菌药物（β-内酰胺类、大环内酯类、氨基糖苷类、四环素类、新型喹诺酮类；NQs）与包括多形核中性粒细胞（PMNs）在内的宿主防御机制协同发挥杀菌或抑菌作用。我们研究了新型喹诺酮类抗菌药物对人PMNs化学发光（CL）反应的影响。在众多NQs中，我们选择了氧氟沙星、洛美沙星、氟罗沙星、司帕沙星、AM-1155、NM-394、Q-35、Y-26611和T-3761。与无药条件相比，25或100微克/毫升的氟罗沙星和氧氟沙星可使PMNs的鲁米诺依赖性CL反应增强1.5至2.0倍。然而，其他抗菌药物则抑制CL反应。这表明就抗菌药物与PMNs之间的相互作用而言，氟罗沙星和氧氟沙星在治疗细菌感染方面更有效。
