Jin H O, Lee K Y, Chang T M, Chey W Y, Dubois A
Department of Medicine, University of Rochester Medical Center, New York.
Dig Dis Sci. 1994 Nov;39(11):2306-14. doi: 10.1007/BF02087643.
We investigated the physiological role of cholecystokinin (CCK) on gastric emptying and acid secretion in seven conscious dogs with gastric cannulae. Two hundred milliliters of a 4% amino acid meal was given via the cannula, and both gastric emptying and acid output were measured concurrently using a dye-dilution technique. Gastric emptying of the liquid amino acid meal was exponential, and the acid output and plasma concentrations of CCK, gastrin, and somatostatin peaked within 30 min after the meal. Intravenous infusion of CCK-8 at 28 and 56 pmol/kg/hr but not 14 pmol/kg/hr increased plasma levels of the peptide and inhibited gastric emptying as well as acid output. Plasma gastrin was not affected significantly by the CCK infusion, whereas plasma somatostatin increased significantly in response to 56 pmol/kg/hr of CCK-8. Loxiglumide, 22 mumol/kg/hr, significantly enhanced gastric emptying and augmented acid output, as well as plasma gastrin response, whereas it abolished the postprandial rise in plasma somatostatin. We concluded that in dogs, CCK plays an important role in the physiologic regulation of postprandial gastric emptying of a liquid caloric meal and acid output. Its inhibitory effect on gastric acid secretion appears to be mediated, at least in part, by somatostatin.
我们在七只装有胃插管的清醒犬中研究了胆囊收缩素（CCK）对胃排空和胃酸分泌的生理作用。通过插管给予200毫升4%的氨基酸餐，并使用染料稀释技术同时测量胃排空和胃酸分泌量。液体氨基酸餐的胃排空呈指数形式，进食后30分钟内胃酸分泌量以及CCK、胃泌素和生长抑素的血浆浓度达到峰值。以28和56 pmol/kg/hr而非14 pmol/kg/hr的速率静脉输注CCK-8可提高该肽的血浆水平，并抑制胃排空和胃酸分泌量。CCK输注对血浆胃泌素无显著影响，而以56 pmol/kg/hr的速率输注CCK-8可使血浆生长抑素显著增加。以22 μmol/kg/hr的速率输注洛西肽显著增强了胃排空，增加了胃酸分泌量以及血浆胃泌素反应，同时消除了餐后血浆生长抑素的升高。我们得出结论，在犬中，CCK在液体热量餐餐后胃排空和胃酸分泌量的生理调节中起重要作用。其对胃酸分泌的抑制作用似乎至少部分是由生长抑素介导的。
