Mangel A W, Koegel A
Am J Physiol. 1984 Apr;246(4 Pt 1):G342-5. doi: 10.1152/ajpgi.1984.246.4.G342.
The effects of peptides on gastric emptying of a liquid meal were studied in rats. Gastric emptying was found to be delayed following intraperitoneal injection of the octapeptide of cholecystokinin (CCK-8). Vasoactive intestinal peptide did not effect emptying, while substance P and neurotensin caused a moderate acceleration in gastric emptying. After oral administration of a solution containing the amino acids tryptophan and phenylalanine, but not glycine, a statistically significant inhibition of gastric emptying was observed. Our results suggest an involvement of CCK in the regulation of gastric emptying.
在大鼠中研究了肽对流食胃排空的影响。腹腔注射胆囊收缩素八肽（CCK-8）后，发现胃排空延迟。血管活性肠肽对排空没有影响，而P物质和神经降压素则使胃排空适度加速。口服含有色氨酸和苯丙氨酸而非甘氨酸的溶液后，观察到胃排空受到统计学上显著的抑制。我们的结果表明CCK参与了胃排空的调节。
