Labouesse M, Sookhareea S, Horvitz H R
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
Development. 1994 Sep;120(9):2359-68. doi: 10.1242/dev.120.9.2359.
The mutation lin-26(n156) prevents vulva formation in C. elegans by transforming the vulval precursor cells into neurons or neuroblasts. We have isolated and characterized three new lin-26 alleles, which result in embryonic lethality. These mutations cause a few other hypodermal cells to express a neural fate and most hypodermal cells to degenerate. lin-26 encodes a presumptive zinc-finger transcription factor. Our data indicate that lin-26 is required for cells to acquire the hypodermal fate.
lin-26(n156)突变通过将秀丽隐杆线虫的外阴前体细胞转化为神经元或神经母细胞来阻止外阴形成。我们已经分离并鉴定了三个新的lin-26等位基因，它们导致胚胎致死。这些突变使其他一些皮下细胞表达神经命运，并使大多数皮下细胞退化。lin-26编码一种推测的锌指转录因子。我们的数据表明，lin-26是细胞获得皮下命运所必需的。
