Adewuyi J O, Gwanzura C
Department of Haematology, University of Zimbabwe.
East Afr Med J. 1994 Mar;71(3):204-6.
The sickle haemoglobin gene (Bs gene) frequency in Zimbabwe was determined by haemoglobin electrophoresis of cord blood samples in a discontinuous alkaline buffer system on cellulose acetate strips. Samples were collected from different regions of the country including malaria-endemic and malaria-free areas and, predominantly Shona and Ndebele speaking areas respectively. 868 samples were analysed and the Bs gene frequency at birth was found to be 0.012. This value was lower than expected probably due to the peculiar topography of Zimbabwe. There was no significant difference in haemoglobin genotype distribution between malarious and non-malarious areas and between ethnic regions. The only exception was for haemoglobin Barts of which there seemed to be an excess in an area of predominantly Ndebele-speaking people.
通过在醋酸纤维素条上的不连续碱性缓冲系统中对脐带血样本进行血红蛋白电泳，测定了津巴布韦的镰状血红蛋白基因（Bs基因）频率。样本采集自该国不同地区，包括疟疾流行区和无疟疾区，且分别主要来自绍纳族和恩德贝莱族聚居区。对868份样本进行了分析，发现出生时的Bs基因频率为0.012。该值低于预期，可能是由于津巴布韦独特的地形所致。疟疾流行区和非流行区之间以及不同民族地区之间的血红蛋白基因型分布没有显著差异。唯一的例外是血红蛋白巴氏，在主要为恩德贝莱族聚居的地区似乎有过量存在。
