Adipudi V, Reddy V K
Department of Zoology, Osmania University, Hyderabad, India.
Eur J Pharmacol. 1994 Jun 23;259(1):7-13. doi: 10.1016/0014-2999(94)90150-3.
Lithium has been extensively used as an antidepressant in the treatment of manic depressive disorders requiring chronic administration. Here, we report a study of the effect of long-term lithium treatment on the activities of membrane adenosine triphosphatases (ATPases) in certain postural muscles of rat. Specifically, Ca(2+)-ATPase, Na+,K(+)-ATPase and Mg(2+)-ATPase activities were measured in the soleus, extensor digitorum longus and plantaris muscles following 6 weeks of treatment with LiCl. Increases were observed in the Na+,K(+)-ATPase activity whereas the Mg(2+)-ATPase activity decreased with prolonged LiCl treatment. The most pronounced effect was a highly significant (P < 0.001) increase in the mitochondrial Ca(2+)-ATPase and Na+,K(+)-ATPase activity to almost 50-100% above the control. The increases in the mitochondrial Ca(2+)-ATPase activity of extensor digitorum longus and plantaris were 70% and 100%, respectively. The corresponding increases in the Na+,K(+)-ATPase activity were 127%, 99% and 87% for soleus, extensor digitorum longus and plantaris, respectively. Irrespective of the differences in the fiber pattern and physiological function, all three muscles responded in a similar way to Li+. The changes in the membrane ATPases reflect a deranged ATP turnover, thus affecting the overall energy state of the animal. Based on these results, we hypothesize that Li+ produces its effects by interfering with cation transport processes. Since Li+ affects the neural excitability of the cell it is suggested that the stimulation of the ATPases may be important in the psychotropic properties of the ion.
锂已被广泛用作抗抑郁药，用于治疗需要长期给药的躁郁症。在此，我们报告一项关于长期锂治疗对大鼠某些姿势肌肉中膜腺苷三磷酸酶（ATP酶）活性影响的研究。具体而言，在用LiCl治疗6周后，测量比目鱼肌、趾长伸肌和跖肌中的Ca(2 +)-ATP酶、Na +,K(+)-ATP酶和Mg(2 +)-ATP酶活性。观察到Na +,K(+)-ATP酶活性增加，而Mg(2 +)-ATP酶活性随着LiCl治疗时间延长而降低。最显著的影响是线粒体Ca(2 +)-ATP酶和Na +,K(+)-ATP酶活性高度显著增加（P < 0.001），比对照高出近50 - 100%。趾长伸肌和跖肌的线粒体Ca(2 +)-ATP酶活性分别增加了70%和100%。比目鱼肌、趾长伸肌和跖肌的Na +,K(+)-ATP酶活性相应增加分别为127%、99%和87%。无论纤维类型和生理功能存在差异，所有三块肌肉对Li +的反应方式相似。膜ATP酶的变化反映了ATP周转紊乱，从而影响动物的整体能量状态。基于这些结果，我们推测Li +通过干扰阳离子转运过程产生其作用。由于Li +影响细胞的神经兴奋性，因此提示ATP酶的刺激可能在该离子的精神otropic特性中起重要作用。
