McLeod R L, Gertner S B, Hey J A
CNS Pharmacology, Schering-Plough Research Institute, Kenilworth, NJ 07033.
Eur J Pharmacol. 1994 Jul 1;259(2):211-4. doi: 10.1016/0014-2999(94)90512-6.
Potential species differences in cardiovascular responses to histamine H3 receptor activation were studied in the conscious guinea pig, rabbit, normotensive rat and the spontaneously hypertensive rat. R-alpha-Methylhistamine (100 micrograms/kg i.v.) decreased blood pressure in both the guinea pig and the rabbit. In the guinea pig, R-alpha-methylhistamine decreased heart rate, whereas in the rabbit it produced a tachycardia. In the normotensive rat and spontaneously hypertensive rat, R-alpha-methylhistamine (100 micrograms/kg i.v.) had no effect on blood pressure and heart rate. The cardiovascular action of R-alpha-methylhistamine in the guinea pig and rabbit was blocked by pretreatment with thioperamide (1.0 mg/kg i.v.) but not by chlorpheniramine (0.3 mg/kg i.v.) or cimetidine (3.0 mg/kg i.v.), respectively. These results indicate species differences in cardiovascular responses to histamine H3 receptor activation.
在清醒的豚鼠、兔子、正常血压大鼠和自发性高血压大鼠中研究了组胺H3受体激活对心血管反应的潜在种属差异。R-α-甲基组胺（静脉注射100微克/千克）可降低豚鼠和兔子的血压。在豚鼠中，R-α-甲基组胺可降低心率，而在兔子中则引起心动过速。在正常血压大鼠和自发性高血压大鼠中，R-α-甲基组胺（静脉注射100微克/千克）对血压和心率无影响。豚鼠和兔子中R-α-甲基组胺的心血管作用分别被硫必利（静脉注射1.0毫克/千克）预处理所阻断，但未被氯苯那敏（静脉注射0.3毫克/千克）或西咪替丁（静脉注射3.0毫克/千克）阻断。这些结果表明组胺H3受体激活对心血管反应存在种属差异。
