大鼠中代谢型谷氨酸受体的激动剂会延迟氟烷麻醉后的恢复。

Agonists for metabotropic glutamate receptors in the rat delay recovery from halothane anesthesia.

作者信息

Miyamoto M, Ishida M, Kwak S, Shinozaki H

机构信息

Department of Pharmacology, Tokyo Metropolitan Institute of Medical Science, Japan.

出版信息

Eur J Pharmacol. 1994 Jul 21;260(1):99-102. doi: 10.1016/0014-2999(94)90016-7.

DOI:10.1016/0014-2999(94)90016-7

PMID:7957632

Abstract

Intraventricular injection of (2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-IV), a potent agonist for metabotropic glutamate receptors, to rats retarded dose-dependently the recovery from halothane anesthesia at a dose range from 30 to 300 pmol/rat. At a dose of 300 pmol/rat, recovery was prolonged up to about 630% of the control. (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine (L-CCG-I) and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD) also delayed recovery, but doses much higher than those of DCG-IV were required (about 300 and 1000 times, respectively). These results suggest that some agonists for a certain kind of metabotropic glutamate receptors have a central depressant action in the rat.

摘要

向大鼠脑室内注射代谢型谷氨酸受体的强效激动剂（2S,1'R,2'R,3'R）-2-（2,3-二羧基环丙基）甘氨酸（DCG-IV），在30至300 pmol/大鼠的剂量范围内，剂量依赖性地延缓了氟烷麻醉后的恢复。在300 pmol/大鼠的剂量下，恢复时间延长至对照的约630%。（2S,1'S,2'S）-2-（羧基环丙基）甘氨酸（L-CCG-I）和（1S,3R）-1-氨基环戊烷-1,3-二羧酸（（1S,3R）-ACPD）也延迟了恢复，但所需剂量远高于DCG-IV（分别约为其300倍和1000倍）。这些结果表明，某些代谢型谷氨酸受体的激动剂在大鼠中具有中枢抑制作用。