Zachariae H
Hautarzt. 1976 Dec;27(12):569-73.
Psoriasis has been treated systemically through most of this century, originally with arsenics, which have been given up due to their carcinogenic effect. Later glucocorticoids were used, but were then abandoned on account of their high frequency of side effects and the appearance of the rebound phenomenon. Cytostatic drugs have been employed for nearly 25 years. Methotrexate is the most common preparation. Methotrexate requires a normal liver-, kidney- and bone marrow function. Pregnancy is an absolute contraindication. Photochemotherapy with oral methoxalen and long wave ultraviolet light is a new treatment which seems promising. This regime, however, is still at a stage of clinical trial.
在本世纪的大部分时间里，银屑病一直采用全身治疗方法，最初使用砷剂，但由于其致癌作用而被放弃。后来使用了糖皮质激素，但因其副作用频繁出现和反弹现象而被摒弃。细胞抑制药物已使用了近25年。甲氨蝶呤是最常用的制剂。甲氨蝶呤需要正常的肝、肾和骨髓功能。怀孕是绝对的禁忌症。口服甲氧沙林和长波紫外线光化学疗法是一种新的治疗方法，似乎很有前景。然而，这种治疗方案仍处于临床试验阶段。
