Guzick D S, Yao Y A, Berga S L, Krasnow J S, Stovall D W, Kubik C J, Zeleznik A J
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Hospital, Pennsylvania.
Fertil Steril. 1994 Dec;62(6):1186-91.
To determine whether pelvic endometriosis impairs the efficacy of GIFT.
Matched follow-up study.
University-based assisted reproduction program.
Patients undergoing GIFT between 1987 and 1991. Cases had a primary diagnosis of endometriosis. Controls had no endometriosis and were matched with cases according to age, number of mature eggs transferred, and sperm grade.
Gamete intrafallopian transfer was performed in all patients in an identical manner independent of their underlying diagnosis.
Pregnancy and delivery rates.
Of 114 laparoscopic egg retrievals performed in the endometriosis group, there were 37 pregnancies (32.5%) and 27 deliveries (23.7%). Of the 214 retrievals in the control group, there were 101 pregnancies (47.2%) and 76 deliveries (35.5%). Mantel-Haenszel estimates of relative risk indicated that endometriosis significantly impaired pregnancy and delivery rates. There was no statistically significant difference in pregnancy rates according to severity of disease among endometriosis cases. There was no statistically significant difference in pregnancy rates according to severity of disease among endometriosis cases.
Our finding that GIFT pregnancy rates were lower in women with a primary diagnosis of endometriosis than in matched controls suggests that endometriosis is associated with reduced efficacy of GIFT.
确定盆腔子宫内膜异位症是否会影响配子输卵管内移植（GIFT）的疗效。
配对随访研究。
大学附属辅助生殖项目。
1987年至1991年间接受GIFT的患者。病例的初步诊断为子宫内膜异位症。对照组无子宫内膜异位症，根据年龄、移植的成熟卵子数量和精子等级与病例进行配对。
所有患者均以相同方式进行配子输卵管内移植，与潜在诊断无关。
妊娠率和分娩率。
子宫内膜异位症组进行了114次腹腔镜取卵，其中37例妊娠（32.5%），27例分娩（23.7%）。对照组214次取卵中，有101例妊娠（47.2%），76例分娩（35.5%）。Mantel-Haenszel相对风险估计表明，子宫内膜异位症显著降低了妊娠率和分娩率。子宫内膜异位症病例中，根据疾病严重程度，妊娠率无统计学显著差异。
我们的研究发现，初步诊断为子宫内膜异位症的女性的GIFT妊娠率低于配对对照组，这表明子宫内膜异位症与GIFT疗效降低有关。
