Pattinson H A, Hignett M, Dunphy B C, Fleetham J A
Department of Obstetrics and Gynecology, Foothills Hospital, Calgary, Alberta, Canada.
Fertil Steril. 1994 Dec;62(6):1192-6. doi: 10.1016/s0015-0282(16)57184-2.
To determine the incidence of ovarian hyperstimulation syndrome (OHSS) and subsequent pregnancy rates (PRs) if ET is delayed in patients at risk of OHSS by allocating all embryos to cryopreservation.
Retrospective analysis of clinical and laboratory data from 724 consecutive stimulated cycles of IVF.
University hospital-based IVF program.
Consecutive patients undergoing IVF between September 1989 and December 1992.
Fertilization rates, cryosurvival rates, subsequent PRs, and the occurrence of severe OHSS.
Ten of the 564 patients (1.8%) who had ET in the stimulation cycle developed severe OHSS. Sixty-nine patients had all embryos frozen because of the risk of OHSS, of which one (1.4%) developed severe OHSS. The subsequent PR after thaw transfer was 25.2% per transfer, with a cumulative PR per patient after additional thaw transfers of 40.6%.
Cryopreservation of all embryos and delayed ET in patients at risk of OHSS results in a low incidence of severe OHSS. Oocyte quality, fertilization rates, and cryosurvival of frozen embryos are equal to those for patients who have a normal stimulation profile. Subsequent thaw embryo replacements result in a satisfactory PR.
通过将所有胚胎进行冷冻保存，确定卵巢过度刺激综合征（OHSS）的发生率以及对于有OHSS风险的患者若胚胎移植（ET）延迟后的后续妊娠率（PRs）。
对724个连续的体外受精（IVF）促排卵周期的临床和实验室数据进行回顾性分析。
大学附属医院的IVF项目。
1989年9月至1992年12月期间连续接受IVF治疗的患者。
受精率、冷冻存活率、后续妊娠率以及严重OHSS的发生情况。
在促排卵周期中进行胚胎移植的564例患者中有10例（1.8%）发生了严重OHSS。69例患者因有OHSS风险而将所有胚胎冷冻，其中1例（1.4%）发生了严重OHSS。解冻移植后的后续妊娠率为每次移植25.2%，在额外解冻移植后每位患者的累积妊娠率为40.6%。
对于有OHSS风险的患者，将所有胚胎冷冻保存并延迟胚胎移植可使严重OHSS的发生率较低。卵母细胞质量、受精率以及冷冻胚胎的冷冻存活率与促排卵情况正常的患者相当。后续解冻胚胎移植可获得令人满意的妊娠率。
