Nakagawa Y, Fuke Y, Irahara M, Aono T
Department of Obstetrics and Gynecology, Tokushima University School of Medicine.
Nihon Naibunpi Gakkai Zasshi. 1994 May 20;70(4):471-7. doi: 10.1507/endocrine1927.70.4_471.
The relationship between maternal plasma levels of beta-endorphin (beta-Ep) during labor and various obstetrical factors was investigated in 115 healthy pregnant women. beta-Ep was determined by radioimmunoassay using double-antibody RIA kit (INCSTAR Corporation, Stillwater, M'S.). The results were as follows: (1) The primiparous women showed a significant increase of maternal plasma levels of beta-Ep at delivery compared with the multiparous women. In addition, the group of women whose Bishop's score at the onset of labor was 5 points or less showed a significant increase of maternal plasma levels of beta-Ep at delivery compared with that in the group of women whose Bishop's score was 6 points or more. (2) The increase in maternal plasma levels of beta-Ep during the first and the second stage of labor was significantly higher in obese women (pre-pregnancy BMI > or = 24) than in normal weight women (pre-pregnancy BMI < 24). In normal weight women in pre-pregnancy, the group of women whose weight gain during pregnancy was 11kg or more showed a significantly higher increase of beta-Ep compared with that in the group of women whose weight gain was less than 11 kg. These results suggest that a stressful delivery caused a significant increase of maternal plasma levels of beta-Ep during labor. Moreover, obesity and marked weight gain during pregnancy caused a remarkable increase in beta-Ep probably due to latent dystocia.
对115名健康孕妇分娩期间母体血浆β-内啡肽（β-Ep）水平与各种产科因素之间的关系进行了研究。使用双抗体放射免疫分析试剂盒（INCSTAR公司，明尼苏达州斯蒂尔沃特）通过放射免疫分析法测定β-Ep。结果如下：（1）初产妇在分娩时母体血浆β-Ep水平比经产妇显著升高。此外，分娩开始时Bishop评分≤5分的产妇组在分娩时母体血浆β-Ep水平比Bishop评分≥6分的产妇组显著升高。（2）肥胖女性（孕前BMI≥24）在第一产程和第二产程期间母体血浆β-Ep水平的升高显著高于正常体重女性（孕前BMI＜24）。在孕前体重正常的女性中，孕期体重增加≥11kg的女性组β-Ep的升高显著高于体重增加＜11kg的女性组。这些结果表明，压力大的分娩会导致分娩期间母体血浆β-Ep水平显著升高。此外，肥胖和孕期体重显著增加可能由于潜在的难产导致β-Ep显著升高。
