Inhibition of prokaryotic and eukaryotic transcription by the 2:1 2,9-dimethyl-1,10-phenanthroline-cuprous complex, a ligand specific for open complexes.
作者信息
Perrin D M, Pearson L, Mazumder A, Sigman D S
机构信息
Department of Biological Chemistry, School of Medicine, University of California at Los Angeles, 90024-1570.
出版信息
Gene. 1994 Nov 4;149(1):173-8. doi: 10.1016/0378-1119(94)90426-x.
PMID:7958982
Abstract
The redox-stable, tetrahedral cuprous chelate of neocuproine (2,9-dimethyl-1,10-phenanthroline) binds to the single-stranded DNA formed in open complexes and is an effective inhibitor of eukaryotic and prokaryotic transcription. Despite the many kinetic and structural differences between prokaryotic and eukaryotic transcription systems, they are all similarly inhibited by neocuproine copper, suggesting that all open complexes may share a homologous structure.
摘要
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