Stornes I, Mejlholm I, Jakobsen A
Department of Oncology, Aarhus University Hospital, Denmark.
Gynecol Oncol. 1994 Oct;55(1):123-5. doi: 10.1006/gyno.1994.1260.
Thirty patients with recurrent squamous cell carcinoma of cervix uteri no longer amenable to control with surgery and/or radiotherapy were treated with a combination of ifosfamide, 5-fluorouracil, and Leucovorin every 4 weeks. The response rate was 53% (complete response, 33%; partial response, 20%). Response rates outside and inside irradiated area were 68 and 27%, respectively. The median progression-free interval was 7 months, and the median overall survival was 12 months. Adverse effects included primarily leukopenia, and dose reduction was necessary in 18 patients (60%). The present combination is active in the treatment of recurrent cervical cancer with a high response rate. The long-term survival is however still unsatisfactory.
30例不再适合手术和/或放疗控制的复发性子宫颈鳞状细胞癌患者，每4周接受异环磷酰胺、5-氟尿嘧啶和亚叶酸联合治疗。缓解率为53%（完全缓解33%；部分缓解20%）。照射区域内外的缓解率分别为68%和27%。无进展生存期的中位数为7个月，总生存期的中位数为12个月。不良反应主要包括白细胞减少，18例患者（60%）需要减少剂量。目前的联合治疗方案在复发性宫颈癌的治疗中具有活性，缓解率高。然而，长期生存率仍不尽人意。
