Stölzle L
Fortschr Med. 1994 Sep 20;112(26):363-4.
Thirty-five patients with endoscopically confirmed duodenal ulcer, histological evidence of Helicobacter pylori, and a history of at least two symptomatic recurrent ulcers consecutively attending a doctor's office were entered into a study investigating the eradication of Helicobacter pylori.
Ranitidine two times 300 mg and roxithromycin two times 300 mg daily for 12 days, together with metronidazole three times 500 mg daily for the first ten days. To achieve final healing of the ulcer, treatment was then continued for a further 16 days with 300 mg ranitidine nocte.
Six weeks after the start of treatment, 32 of the 35 patients were Helicobacter pylori-negative and their ulcers had all healed completely. Five of the 35 patients reported mild side effects (diarrhea, temporary nausea).
35例经内镜确诊为十二指肠溃疡、有幽门螺杆菌组织学证据且有至少两次有症状的复发性溃疡病史并连续到医生办公室就诊的患者进入一项研究，该研究旨在调查幽门螺杆菌的根除情况。
雷尼替丁每日2次，每次300毫克，罗红霉素每日2次，每次300毫克，共12天，同时甲硝唑在前10天每日3次，每次500毫克。为使溃疡最终愈合，随后继续用雷尼替丁每晚300毫克治疗16天。
治疗开始6周后，35例患者中有32例幽门螺杆菌检测呈阴性，且他们的溃疡均已完全愈合。35例患者中有5例报告有轻微副作用（腹泻、暂时性恶心）。
