Mandich P, Schito A M, Bellone E, Antonacci R, Finelli P, Rocchi M, Ajmar F
Institute of Biology and Genetics (IBiG), University of Genoa, Italy.
Genomics. 1994 Jul 1;22(1):216-8. doi: 10.1006/geno.1994.1366.
The N-methyl-D-aspartate (NMDA) receptor channel is essential for synaptic transmission and synaptic plasticity underlying memory, learning, and development. Three subunits of the NMDA receptor channel, NMDAR2A, NMDAR2B, and NMDAR2C (NR2A, NR2B, and NR2C), previously identified in mouse by cDNA cloning and expression, share a high level of homology, although their patterns of expression within the brain may differ. In the present work we report the localization of the gene encoding the human NMDAR2B receptor subunit (called GRIN2B for glutamate receptor, ionotropic, N-methyl-D-aspartate 2B) to chromosome 12p12 by in situ hybridization and somatic cell hybrids.
N-甲基-D-天冬氨酸（NMDA）受体通道对于突触传递以及记忆、学习和发育所依赖的突触可塑性至关重要。NMDA受体通道的三个亚基，即之前通过cDNA克隆和表达在小鼠中鉴定出的NMDAR2A、NMDAR2B和NMDAR2C（NR2A、NR2B和NR2C），尽管它们在脑内的表达模式可能不同，但具有高度的同源性。在本研究中，我们通过原位杂交和体细胞杂种技术，报告了编码人类NMDAR2B受体亚基（称为GRIN2B，即离子型谷氨酸受体，N-甲基-D-天冬氨酸2B）的基因定位于染色体12p12。
