Saha A, Balakrishnan K G, Jaiswal P K, Venkitachalam C G, Tharakan J, Titus T, Kutty R
Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
Int J Cardiol. 1994 Jul;45(3):199-207. doi: 10.1016/0167-5273(94)90166-x.
The objective of this study was to determine the long-term survival pattern and variables affecting long-term survival and complications occurring during follow-up of patients with Eisenmenger syndrome. A retrospective study of patients diagnosed with Eisenmenger syndrome were followed up. A tertiary care centre was used and it provided superspeciality services in various disciplines. The subjects included 201 patients with Eisenmenger syndrome--diagnosed by a combination of echocardiography and a peripheral arterial oxygen saturation study and/or cardiac catheterisation with or without angiocardiography--worked up and followed up for variable duration over a period of 16 years from 1976 to 1992. One hundred nine patients were females and 92 were males--age of presentation varied from 3 months to 62 years (mean +/- standard deviation 19.23 +/- 12.62 years). A total of 12 different anatomic lesions were seen--the most common three being ventricular septal defect (33.33%), aterial septal defect (29.85%), and patent ductus arteriosus (14.23%). History, physical examination, chest skiagram and electrocardiogram established only the presence of pulmonary arterial hypertension except where differential cyanosis indicating ductus was discernible or the degree of splitting of second heart sound provided some clue to the level of shunt. Contrast echocardiography, completed in 25.4% established the level of shunt in all patients. In others the diagnosis was confirmed by cardiac catheterisation. Twenty patients died during a mean follow-up period of 54.6 +/- 54.47 months. Sudden cardiac deaths (30%), congestive heart failure (25%) and haemoptysis (15%) were the most predominant causes of death. Only one patient died during puerperium.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的目的是确定艾森曼格综合征患者的长期生存模式、影响长期生存的变量以及随访期间出现的并发症。对诊断为艾森曼格综合征的患者进行了回顾性研究并随访。研究使用了一家三级医疗中心，该中心提供各学科的超专科服务。研究对象包括201例艾森曼格综合征患者，这些患者通过超声心动图与外周动脉血氧饱和度研究和/或心脏导管检查（有或无心血管造影）相结合的方法进行诊断，于1976年至1992年的16年间进行了不同时长的检查和随访。109例为女性，92例为男性，发病年龄从3个月至62岁不等（平均±标准差为19.23±12.62岁）。共观察到12种不同的解剖病变，最常见的三种是室间隔缺损（33.33%）、房间隔缺损（29.85%）和动脉导管未闭（14.23%）。病史、体格检查、胸部X线片和心电图仅能确定肺动脉高压的存在，除非可观察到提示动脉导管的差异性发绀，或第二心音分裂程度为分流水平提供了一些线索。25.4%的患者完成了对比超声心动图检查，确定了所有患者的分流水平。其他患者则通过心脏导管检查确诊。在平均54.6±54.47个月的随访期内，有20例患者死亡。心源性猝死（30%）、充血性心力衰竭（25%）和咯血（15%）是最主要的死亡原因。只有1例患者在产褥期死亡。（摘要截断于250字）
