Ojutkangas R, Gillman M A
South African Brain Research Institute, Waverely, Johannesburg.
Int J Neurosci. 1994 May;76(1-2):35-9. doi: 10.3109/00207459408985989.
In a retrospective study of 500 patients we present evidence that psychotropic analgesic nitrous oxide (PAN) can be used safely and successfully as an out-patient treatment for the AWS in the vast majority of cases. A feature of the PAN therapy is the rapidity of recovery of patients within 60 minutes; which is in stark contrast to that found when traditional benzodiazepine medication regimens are used. Our work confirms earlier findings confined to in-patients. Importantly, the requirements for addictive sedative medications is also dramatically reduced, greatly diminishing the dangers of secondary addiction. In a small number of cases PAN can be used to treat alcohol craving, which may prevent relapses through its positive effects on reducing craving. The promising, rapid anti-craving effects of PAN would seem to require further investigation to establish when it is likely to be of benefit in preventing relapse. In order to maximize the benefit of the PAN treatment to both patient and physician it is essential for the physician to undergo a short hands-on training course.
在一项对500名患者的回顾性研究中,我们提供了证据表明,在绝大多数情况下,精神类镇痛剂一氧化二氮(PAN)可作为门诊治疗酒精戒断综合征(AWS)的一种安全且成功的方法。PAN疗法的一个特点是患者能在60分钟内迅速恢复,这与使用传统苯二氮䓬类药物治疗方案时的情况形成鲜明对比。我们的研究证实了早期仅限于住院患者的研究结果。重要的是,成瘾性镇静药物的需求也大幅减少,极大地降低了继发性成瘾的风险。在少数情况下,PAN可用于治疗酒瘾,它对减少渴望的积极作用可能会预防复发。PAN有前景的快速抗渴望效果似乎需要进一步研究,以确定其在预防复发方面可能有益的时机。为了使PAN治疗对患者和医生都能发挥最大益处,医生必须参加一个简短的实践培训课程。