Hayes F J, Redmond J M, McKenna M J
Department of Endocrinology, Diabetes & Metabolism, St. Vincent's Hospital, Dublin.
Ir Med J. 1994 Sep-Oct;87(5):150-1.
We describe two patients with type 2 diabetes who presented with abdominal pain secondary to thoracic polyradiculopathy. In the first patient abdominal pain occurred in association with marked abdominal distension; extensive negative gastrointestinal investigations were performed before the correct diagnosis was made by electromyography showing thoracic paraspinal muscle denervation. In the second case, truncal sensory symptoms alone were evident at the time of diagnosis of diabetes mellitus. While muscle laxity was absent, extensive paraspinal muscle denervation was detected. Tolrestat, an aldose reductase inhibitor, was associated with good clinical response of symptoms due to peripheral neuropathy and thoracic polyradiculopathy. The pathogenesis of thoracic polyradiculopathy is uncertain but is likely to be the result of multiple infarcts along the course of thoracic spinal nerves accounting.
我们描述了两名2型糖尿病患者，他们因胸段多发性神经根病而出现腹痛。在第一例患者中，腹痛与明显的腹胀同时出现；在通过肌电图显示胸段椎旁肌失神经支配而做出正确诊断之前，进行了广泛的阴性胃肠道检查。在第二例中，在诊断糖尿病时仅出现躯干感觉症状。虽然没有肌肉松弛，但检测到广泛的椎旁肌失神经支配。醛糖还原酶抑制剂托瑞司他与周围神经病变和胸段多发性神经根病所致症状的良好临床反应相关。胸段多发性神经根病的发病机制尚不确定，但可能是胸段脊神经走行过程中多处梗死的结果。
