Breuninger H, Köhler C, Drepper H, Bastian B, Bröcker E B, Göhl J, Groth W, Hermanek P, Hohenberger W, Lippold A
Universitäts-Hautklinik Tübingen.
Hautarzt. 1994 Aug;45(8):529-31. doi: 10.1007/s001050050120.
Even today, the prognosis of acrallentiginous melanoma (ALM) remains a controversial topic. We present a large case study including all known factors relevant for prognosis. 113 ALMs in 3616 melanoma patients were paired as precisely as possible with their twins, i.e. with 113 superficial spreading melanomas (SSM) from a group of 619 SSMs with high-risk location. The ALMs and SSMs were equivalent in tumor thickness, patient gender and mode of treatment. The follow-up period was for at least 5 years. The 5-year Kaplan-Meier survival curve in both groups are identical. The poor prognosis often ascribed to ALM results from the prognostic factor location. ALM should therefore be regarded as acral localized melanoma.
即使在今天，肢端雀斑样痣性黑色素瘤（ALM）的预后仍然是一个有争议的话题。我们进行了一项大型病例研究，纳入了所有与预后相关的已知因素。在3616例黑色素瘤患者中的113例ALM尽可能精确地与它们的配对肿瘤，即从一组619例具有高危部位的浅表扩散性黑色素瘤（SSM）中选取的113例SSM进行配对。ALM和SSM在肿瘤厚度、患者性别和治疗方式方面相当。随访期至少为5年。两组的5年Kaplan-Meier生存曲线相同。通常归因于ALM的预后不良是由预后因素部位导致的。因此，ALM应被视为肢端局限性黑色素瘤。
