Mooradian A D, Habib M P, Dickerson F, Yetskievych T
Department of Medicine, St. Louis University Health Sciences Center, Missouri 63104.
J Appl Physiol (1985). 1994 Jul;77(1):160-4. doi: 10.1152/jappl.1994.77.1.160.
The effect of age on thyroid hormone-induced lipid peroxidation in rats was determined by measuring ethane exhalation (EE) rate. The mean basal EE rates (in pmol.min-1 x 100 g-1) at room air in 25-mo-old aged rats [3.07 +/- 0.26 (SE)] and in intermediate age (18-mo-old) rats (3.42 +/- 0.18) were significantly lower than that in young (3- to 5-mo-old) rats (4.44 +/- 0.27) (P < 0.01). After 8 days of L-3,5,3'-triiodothyronine (T3) administration, EE rates in aged rats (4.10 +/- 0.25) and in intermediate-age rats (4.16 +/- 0.35) were significantly lower than that in young rats (5.61 +/- 0.36) (P < 0.01). T3-treated young rats pair-fed with aged rats for 2 wk had EE rates (5.53 +/- 0.18) comparable to ad libitum-fed young rats, although the basal rate of EE was significantly reduced with partial food restriction (4.44 +/- 0.27 vs. 3.50 +/- 0.24) (P < 0.01). These observations indicate that reduced food intake with age cannot account for the age-related changes in T3-stimulated peroxidation rate of lipids.
通过测量乙烷呼出率（EE）来确定年龄对大鼠甲状腺激素诱导的脂质过氧化的影响。25月龄老年大鼠[3.07±0.26（标准误）]和中年（18月龄）大鼠（3.42±0.18）在室内空气中的平均基础EE率（单位：pmol·min⁻¹×100g⁻¹）显著低于年轻（3至5月龄）大鼠（4.44±0.27）（P<0.01）。给予L-3,5,3'-三碘甲状腺原氨酸（T3）8天后，老年大鼠（4.10±0.25）和中年大鼠（4.16±0.35）的EE率显著低于年轻大鼠（5.61±0.36）（P<0.01）。与老年大鼠配对喂养2周的T3处理年轻大鼠的EE率（5.53±0.18）与自由采食的年轻大鼠相当，尽管部分食物限制使基础EE率显著降低（4.44±0.27对3.50±0.24）（P<0.01）。这些观察结果表明，随着年龄增长食物摄入量减少并不能解释与年龄相关的T3刺激脂质过氧化率的变化。
