Leadbetter R A, Shutty M S
University of Virginia, Charlottesville.
J Clin Psychiatry. 1994 Sep;55 Suppl B:110-3.
Recent reports indicate that clozapine may dramatically decrease both polydipsia and intermittent hyponatremia associated with chronic psychosis. In contrast, there are conflicting reports regarding the impact of standard neuroleptic treatment in this syndrome. We review the relevant literature examining the effects of antipsychotics on the excessive thirst drive and inordinate arginine vasopressin activity observed in patients with water intoxication. Confounding interpretation of the current literature are inconsistent use of diagnostic criteria and treatment outcome measures. If results of preliminary trials is substantiated, clozapine treatment may provide an opportunity to correct methodological problems and provide greater insight into the syndrome of polydipsia and intermittent hyponatremia.
最近的报告表明，氯氮平可能会显著降低与慢性精神病相关的烦渴和间歇性低钠血症。相比之下，关于标准抗精神病药物治疗对该综合征影响的报告相互矛盾。我们回顾了相关文献，研究了抗精神病药物对水中毒患者过度口渴驱动力和异常精氨酸加压素活性的影响。目前文献的混淆解释在于诊断标准和治疗结果测量方法的不一致使用。如果初步试验结果得到证实，氯氮平治疗可能会提供一个机会来纠正方法学问题，并更深入地了解烦渴和间歇性低钠血症综合征。
