Farde L, Nordström A L, Nyberg S, Halldin C, Sedvall G
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
J Clin Psychiatry. 1994 Sep;55 Suppl B:67-9.
Positron emission tomography (PET) and selective radioligands were used to determine central D1- and D2-dopamine- and 5-HT2-receptor occupancy in clozapine-treated patients with schizophrenia. In 16 patients, the mean D2-receptor occupancy was 47% (range, 20%-67%), which is lower than that previously demonstrated in patients treated with classical neuroleptics (range, 70%-89%). In 11 patients, the mean D1-receptor occupancy was 44% (range, 33%-59%), which is high when compared with that for classical neuroleptics. In a group of 5 patients, including some treated with low doses of clozapine, the mean 5-HT2-receptor occupancy was a high 89% (range, 84%-94%). By comparison to classical neuroleptics, clozapine is atypical with regard to central binding characteristics in the brain of treated patients.
正电子发射断层扫描（PET）和选择性放射性配体被用于测定接受氯氮平治疗的精神分裂症患者大脑中D1和D2多巴胺受体以及5-HT2受体的占有率。在16例患者中，D2受体的平均占有率为47%（范围为20%-67%），低于先前在接受传统抗精神病药物治疗的患者中所显示的占有率（范围为70%-89%）。在11例患者中，D1受体的平均占有率为44%（范围为33%-59%），与传统抗精神病药物相比这一占有率较高。在一组5例患者中，包括一些接受低剂量氯氮平治疗的患者，5-HT2受体的平均占有率高达89%（范围为84%-94%）。与传统抗精神病药物相比，氯氮平在接受治疗患者大脑中的中枢结合特性方面属于非典型药物。
